| Insert |
DNA: genomic Insert lengths(kb): 12.0 Tissue: fetal liver Gene product: immunoglobulin mu [IGHM] Alleles: C6, D2, B3, F1, A1, A2, A3, A4, B1, B2, C1, C2, C3, C4, C5, D1, E2, E3, F2, E1, E4 |
| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--22.0, 12.5 (arms); 9.4, 1.45, 1.2, 1.0 (insert). The insert contains the Cmu switch region and the mu constant region gene. Alleles A5 - A8 are additional alleles for the SstI deletion polymorphism which have a combined frequency of 0.04. |
| References |
Takahashi N, et al. Cloning of human immmunoglobulin mu gene and comparison with mouse mu gene. Nucleic Acids Res. 8: 5983-5991, 1980. PubMed: 6450943
Migone N, et al. Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc. Natl. Acad. Sci. USA 80: 467-471, 1983. PubMed: 6300846
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